[The complement system and its possible role in the pathogenesis of age-related macular degeneration (AMD)].

Authors :: Charbel Issa P
Scholl HP
Holz FG
Knolle P
Kurts C
Source :: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft [Ophthalmologe] 2005 Nov; Vol. 102 (11), pp. 1036-42.
Publication Year :: 2005
Abstract: The discovery of the complement factor H (CFH) polymorphism in age-related macular degeneration (AMD) strongly suggests a causative role of the complement system in the pathogenesis of this disease. The complement system is part of the innate immune system and is closely associated with the cellular response and the adaptive immune system. This article provides an overview of the complement system and, taking the new data into account, of possible immunopathogenetic processes in AMD.

Subjects :: Complement Factor H immunology
Humans
Bruch Membrane immunology
Macular Degeneration immunology
Models, Immunological
Pigment Epithelium of Eye immunology

Language :: German
ISSN :: 0941-293X
Volume :: 102
Issue :: 11
Database :: MEDLINE
Journal :: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Publication Type :: Academic Journal
Accession number :: 16215754
Full Text :: https://doi.org/10.1007/s00347-005-1269-4

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