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Meniscal replacement in dogs. Tissue regeneration in two different materials with similar properties.
- Source :
-
Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2006 Feb; Vol. 76 (2), pp. 389-96. - Publication Year :
- 2006
-
Abstract
- In earlier studies, meniscal replacement with a porous polymer implant led to regeneration of neo-meniscal tissue. To evaluate the influence of the chemical properties on the tissue regeneration in the implant, in the present study, the meniscus in the dog's knee was replaced with either an aromatic 4,4-diphenylmethanediisocyanate based polyesterurethane implant (Estane) (n = 6) or with an aliphatic 1,4-butanediisocyanate based polyesterurethane implant (PCLPU) (n = 6). After 6 months, the knee joints were resected and the tissue behavior in the two different prostheses was evaluated microscopically. In both prostheses, a meniscus-like distribution of the tissue phenotype was found with collagen type I in the peripheral fibrous zones and collagen type II in the central, more cartilaginous zones. The compression-stress behavior of the implant-tissue construct remained in between the stiffness of the polymer material and that of the native meniscus. The PCLPU implant seemed to provoke less synovial tissue reaction. After meniscectomy solely, in 5 out of 6 cases, a meniscus-like regenerate was formed. Furthermore, the articular cartilage degeneration after placing a PCLPU implant did also not exceed the degeneration after the Estane implant or after meniscectomy. The differences between these two implants did not seem to influence the tissue regeneration in the implant. However, PCLPU seemed to evoke less tissue reaction and, therefore, is thought to be less or even nontoxic as compared with the Estane implant. Therefore, for studies in the future, the authors prefer the PCLPU prostheses for replacement of the meniscus.<br /> (Copyright 2005 Wiley Periodicals, Inc.)
- Subjects :
- Animals
Biocompatible Materials chemistry
Biocompatible Materials metabolism
Biomedical Engineering
Collagen Type I metabolism
Collagen Type II metabolism
Dogs
Female
Male
Materials Testing
Molecular Structure
Surface Properties
Implants, Experimental
Menisci, Tibial anatomy & histology
Menisci, Tibial surgery
Polyesters chemistry
Polyesters metabolism
Polyurethanes chemistry
Polyurethanes metabolism
Regeneration
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4973
- Volume :
- 76
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of biomedical materials research. Part B, Applied biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 16211565
- Full Text :
- https://doi.org/10.1002/jbm.b.30406