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Targeting the epigenome for the treatment and prevention of lung cancer.
- Source :
-
Seminars in oncology [Semin Oncol] 2005 Oct; Vol. 32 (5), pp. 488-502. - Publication Year :
- 2005
-
Abstract
- Alterations in chromatin structure resulting from aberrant DNA methylation and perturbations of the histone code profoundly influence gene expression during pulmonary carcinogenesis. Recent studies indicate that DNA demethylating agents and histone deacetylase (HDAC) inhibitors synergistically induce gene expression and apoptosis in cultured lung cancer cells, and prevent lung cancer development in animals following exposure to tobacco carcinogens. Preliminary clinical trials have established proof of principle regarding the use of DNA demethylating agents and HDAC inhibitors for enhancing immunogenicity and apoptosis of lung cancer cells, and have revealed the complexities concerning the mechanisms by which chromatin remodeling agents mediate antitumor effects in vivo. These data support additional investigations pertaining to the epigenetics of lung cancer, and the evaluation of chromatin remodeling agents for the treatment and prevention of this disease.
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Apoptosis
Cell Line, Tumor
Chromatin metabolism
Clinical Trials as Topic
DNA Methylation
Enzyme Inhibitors pharmacology
Flow Cytometry
Histone Deacetylase Inhibitors
Histones metabolism
Humans
Lung Neoplasms metabolism
Time Factors
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Lung Neoplasms drug therapy
Lung Neoplasms genetics
Lung Neoplasms prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0093-7754
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Seminars in oncology
- Publication Type :
- Academic Journal
- Accession number :
- 16210090
- Full Text :
- https://doi.org/10.1053/j.seminoncol.2005.07.007