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Evolution of purely infratentorial PML under HAART--negative outcome under rapid immune reconstitution.
- Source :
-
Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2005 Oct; Vol. 107 (6), pp. 509-13. Date of Electronic Publication: 2004 Nov 11. - Publication Year :
- 2005
-
Abstract
- Progressive multifocal leukoencephalopathy (PML) caused by the polyomavirus JC is a well-recognised complication of AIDS. Purely infratentorial manifestations are rare. Introduction of highly active antiretroviral therapy (HAART) has been associated with a reduction in morbidity and an improvement in overall survival among HIV-infected individuals. Recently, several reports have described adverse events in patients with PML who begin HAART and show evidence for immune reconstitution. We describe the clinical course of two patients with PML with purely infratentorial manifestation, whose clinical course deteriorated despite the successful introduction of HAART. Possible underlying immunological mechanisms are discussed.
- Subjects :
- Adult
Brain Stem drug effects
Brain Stem immunology
CD4 Lymphocyte Count
CD4-CD8 Ratio
Cerebellar Diseases chemically induced
Cerebellar Diseases diagnosis
Cerebellar Diseases immunology
Disease Progression
Fatal Outcome
HIV Infections immunology
Humans
Leukoencephalopathy, Progressive Multifocal diagnosis
Leukoencephalopathy, Progressive Multifocal immunology
Magnetic Resonance Imaging
Male
Neurologic Examination drug effects
Treatment Outcome
Antiretroviral Therapy, Highly Active adverse effects
HIV Infections drug therapy
Leukoencephalopathy, Progressive Multifocal chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0303-8467
- Volume :
- 107
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical neurology and neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 16202824
- Full Text :
- https://doi.org/10.1016/j.clineuro.2004.10.005