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Ocular 'non-scarring' mucous membrane pemphigoid associated with anti-laminin-5 antibodies.
- Source :
-
Clinical and experimental dermatology [Clin Exp Dermatol] 2005 Nov; Vol. 30 (6), pp. 679-81. - Publication Year :
- 2005
-
Abstract
- Mucous membrane pemphigoid is a rare, chronic autoimmune disease characterized by subepidermal blistering and scarring, predominantly affecting mucous membranes. Ocular involvement frequently occurs and often represents the only manifestation of the disease. We describe a 62-year-old woman with a bilateral 18-month duration of conjunctival hyperaemia, associated with erythema and oedema of the eyelids, lacking any typical ocular signs of mucous membrane pemphigoid such as sub-conjuctival fibrosis and scarring. Histology was not significant. Direct immunofluorescence of the conjunctiva showed IgG, IgA and complement deposition along the basement membrane zone. Immunoprecipitation analysis of affinity purified laminin-5 revealed a band consistent with the beta3 chain of laminin-5. This represents the first case of pure ocular mucous membrane pemphigoid associated with anti-laminin-5 antibodies.
Details
- Language :
- English
- ISSN :
- 0307-6938
- Volume :
- 30
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical and experimental dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 16197388
- Full Text :
- https://doi.org/10.1111/j.1365-2230.2005.01923.x