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Rapamycin analogs with reduced systemic exposure.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Dec 01; Vol. 15 (23), pp. 5340-3. Date of Electronic Publication: 2005 Sep 26. - Publication Year :
- 2005
-
Abstract
- The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared with rapamycin.
- Subjects :
- Animals
Antirheumatic Agents toxicity
Arthritis, Rheumatoid diagnostic imaging
Arthritis, Rheumatoid drug therapy
Male
Radiography
Rats
Rats, Inbred Lew
Rats, Sprague-Dawley
Antirheumatic Agents chemistry
Antirheumatic Agents pharmacokinetics
Arthritis, Rheumatoid metabolism
Sirolimus analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 15
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16185865
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.06.106