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Role of B cells in vaccine-induced immunity against coccidioidomycosis.
- Source :
-
Infection and immunity [Infect Immun] 2005 Oct; Vol. 73 (10), pp. 7011-3. - Publication Year :
- 2005
-
Abstract
- We investigated secondary immunity against coccidioidomycosis by using gene expression microarrays. Surprisingly, a high percentage of B-cell-related genes were associated with protective immunity. A functional confirmation of the importance of B cells against coccidioidomycosis was achieved by demonstrating that vaccination was not fully protective in B-cell-deficient MuMT mice.
- Subjects :
- Animals
Coccidioidomycosis genetics
Coccidioidomycosis prevention & control
Female
Fungal Vaccines therapeutic use
Gene Expression Profiling
Genes, Immunoglobulin
Immunization
Male
Mice
Mice, Mutant Strains
Oligonucleotide Array Sequence Analysis
B-Lymphocytes immunology
Coccidioidomycosis immunology
Fungal Vaccines immunology
Gene Expression Regulation
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 73
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 16177382
- Full Text :
- https://doi.org/10.1128/IAI.73.10.7011-7013.2005