Human chorionic gonadotropin in cervical fluid as a predictor of miscarriage.

Objective: To determine whether the concentration of hCG in cervical fluid can predict miscarriage during early pregnancy.
Design: Prospective clinical study.
Setting: University hospital.
Patient(s): Ninety-nine women with singleton pregnancies, 17 of whom suffered a miscarriage.
Intervention(s): None.
Main Outcome Measure(s): Miscarriage and the cervical fluid/serum hCG concentration ratio.
Result(s): With a cutoff value of 1.0, the sensitivity, specificity, and positive and negative predictive values of the cervical fluid/serum hCG concentration ratio for predicting miscarriage were 88.2%, 94.9%, 83.3%, and 96.6%, respectively.
Conclusion(s): The cervical fluid/serum hCG concentration ratio might be a useful predictor of miscarriage during early pregnancy.