Back to Search
Start Over
A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Nov 15; Vol. 15 (22), pp. 4989-93. - Publication Year :
- 2005
-
Abstract
- Bisaryl cyclic ureas have been identified as high affinity 5-HT2C receptor antagonists with selectivity over 5-HT2A and 5-HT2B. Compounds such as 8 and 22 have shown oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function in rodents.
- Subjects :
- Administration, Oral
Animals
Cell Line
Humans
Imidazolidines chemical synthesis
Imidazolidines chemistry
Molecular Structure
Rats
Receptor, Serotonin, 5-HT2A metabolism
Receptor, Serotonin, 5-HT2B metabolism
Receptor, Serotonin, 5-HT2C metabolism
Sensitivity and Specificity
Structure-Activity Relationship
Substrate Specificity
Imidazolidines administration & dosage
Imidazolidines pharmacology
Serotonin 5-HT2 Receptor Antagonists
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 15
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16168649
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.08.004