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Pharmacotherapy of epileptic seizures in glioma patients: who, when, why and how long?
- Source :
-
Onkologie [Onkologie] 2005 Aug; Vol. 28 (8-9), pp. 391-6. Date of Electronic Publication: 2005 Aug 29. - Publication Year :
- 2005
-
Abstract
- Background: The risk for patients with primary brain tumors of experiencing an epileptic seizure at least once in the course of disease probably exceeds 50%, depending on tumor location and tumor type. Several aspects regarding the role of anticonvulsants in the treatment of brain tumor patients have remained controversial.<br />Patients and Methods: We reviewed the seizure history in 107 patients undergoing a surgical procedure for glioma at our institution.<br />Results: The overall seizure incidence was 68%. Pre-operative seizures did not predict the occurrence of post-operative seizures. After surgery, postoperative chemo- or radiotherapy and anticonvulsive therapy one third of patients was seizure-free whereas one third showed frequent seizures despite this treatment. Seizure frequency increased regardless of anticonvulsive treatment with progressive or recurrent tumor growth.<br />Conclusions: Based on a literature review and our institutional experience, we delineate some recommendations for the management of seizures in patients with brain tumors.
- Subjects :
- Adolescent
Adult
Aged
Anticonvulsants adverse effects
Antineoplastic Agents administration & dosage
Antineoplastic Agents adverse effects
Brain Neoplasms diagnosis
Brain Neoplasms drug therapy
Brain Neoplasms surgery
Chemotherapy, Adjuvant
Combined Modality Therapy
Disease Progression
Drug Interactions
Epilepsies, Partial etiology
Female
Glioma diagnosis
Glioma drug therapy
Glioma surgery
Humans
Male
Middle Aged
Neoplasm Recurrence, Local complications
Neoplasm Recurrence, Local diagnosis
Retrospective Studies
Anticonvulsants administration & dosage
Brain Neoplasms complications
Cerebral Cortex drug effects
Cerebral Cortex surgery
Epilepsies, Partial drug therapy
Glioma complications
Subjects
Details
- Language :
- English
- ISSN :
- 0378-584X
- Volume :
- 28
- Issue :
- 8-9
- Database :
- MEDLINE
- Journal :
- Onkologie
- Publication Type :
- Academic Journal
- Accession number :
- 16160401
- Full Text :
- https://doi.org/10.1159/000086375