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Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats.
- Source :
-
Bioelectromagnetics [Bioelectromagnetics] 2005 Oct; Vol. 26 (7), pp. 578-88. - Publication Year :
- 2005
-
Abstract
- Possible effects of 1439 MHz electromagnetic near field (EMF) exposure on the blood-brain barrier (BBB) were investigated using immature (4 weeks old) and young (10 weeks old) rats, equivalent in age to the time when the BBB development is completed and the young adult, respectively. Alteration of BBB related genes, such as those encoding p-glycoprotein, aquaporin-4, and claudin-5, was assessed at the protein and mRNA levels in the brain after local exposure of the head to EMF at 0, 2, and 6 W/kg specific energy absorption rates (SARs) for 90 min/day for 1 or 2 weeks. Although expression of the 3 genes was clearly decreased after administration of 1,3-dinitrobenzene (DNB) as a positive control, when compared with the control values, there were no pathologically relevant differences with the EMF at any exposure levels at either age. Vascular permeability, monitored with reference to transfer of FITC-dextran, FD20, was not affected by EMF exposure. Thus, these findings suggest that local exposure of the head to 1439 MHz EMF exerts no adverse effects on the BBB in immature and young rats.<br /> ((c) 2005 Wiley-Liss, Inc.)
- Subjects :
- Aging radiation effects
Animals
Blood-Brain Barrier radiation effects
Capillary Permeability radiation effects
Cell Membrane Permeability physiology
Cell Membrane Permeability radiation effects
Cell Phone
Cells, Cultured
Claudin-5
Dose-Response Relationship, Radiation
Male
Radiation Dosage
Rats
Rats, Inbred F344
ATP Binding Cassette Transporter, Subfamily B, Member 1 metabolism
Aging physiology
Aquaporin 4 metabolism
Blood-Brain Barrier physiology
Capillary Permeability physiology
Electromagnetic Fields
Membrane Proteins metabolism
Microwaves
Subjects
Details
- Language :
- English
- ISSN :
- 0197-8462
- Volume :
- 26
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioelectromagnetics
- Publication Type :
- Academic Journal
- Accession number :
- 16142770
- Full Text :
- https://doi.org/10.1002/bem.20138