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Multiscale modeling of lipids and lipid bilayers.

Authors :
Lyubartsev AP
Source :
European biophysics journal : EBJ [Eur Biophys J] 2005 Dec; Vol. 35 (1), pp. 53-61. Date of Electronic Publication: 2005 Aug 31.
Publication Year :
2005

Abstract

A multiscale modeling approach is applied for simulations of lipids and lipid assemblies on mesoscale. First, molecular dynamics simulation of initially disordered system of lipid molecules in water within all-atomic model was carried out. On the next stage, structural data obtained from the molecular dynamics (MD) simulation were used to build a coarse-grained (ten sites) lipid model, with effective interaction potentials computed by the inverse Monte Carlo method. Finally, several simulations of the coarse-grained model on longer length- and time-scale were performed, both within Monte Carlo and molecular dynamics simulations: a periodical sample of lipid molecules ordered in bilayer, a free sheet of such bilayer without periodic boundary conditions, formation of vesicle from a plain membrane, process of self-assembly of lipids randomly dispersed in volume. It was shown that the coarse-grained model, developed exclusively from all-atomic simulation data, reproduces well all the basic features of lipids in water solution.

Details

Language :
English
ISSN :
0175-7571
Volume :
35
Issue :
1
Database :
MEDLINE
Journal :
European biophysics journal : EBJ
Publication Type :
Academic Journal
Accession number :
16133633
Full Text :
https://doi.org/10.1007/s00249-005-0005-y