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A poly(propylene glycol-co-fumaric acid) based bone graft extender for lumbar spinal fusion: in vivo assessment in a rabbit model.
- Source :
-
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society [Eur Spine J] 2006 Jun; Vol. 15 (6), pp. 936-43. Date of Electronic Publication: 2005 Aug 13. - Publication Year :
- 2006
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Abstract
- Study Design: An animal model of posterolateral intertransverse process lumbar spinal fusion compared fusion rates amongst autologous bone (group 1), a porous, bioabsorbable, scaffold based on the biopolymer, poly(propylene glycol-co-fumaric acid) (PPF) (group 2), and a combination of autograft and the bioabsorbable scaffold (group 3).<br />Objectives: To evaluate the feasibility of augmenting spinal fusion with an osteoconductive and bioabsorbable scaffold as an alternative or as an adjunct, i.e., an extender, to autograft.<br />Summary of Background Data: There is little preclinical data on applications of bioabsorable bone graft extenders in spinal fusion.<br />Methods: New Zealand White rabbits underwent single-level lumbar posterolateral intertransverse process fusion. Animals were treated with one of three materials: autologous bone (group 1), a bioabsorable material based on PPF (group 2), and the PPF biopolymer scaffold with autologous bone graft (group 3). Animals were evaluated at 6 weeks, and fusion was evaluated by manual palpation, and radiographic, histologic, and histomorphometric analyses.<br />Results: Radiographic and manual palpation showed evidence of fusion in all three groups. Histomorphometric measurement of bone ingrowth showed the highest quantity of new bone in group 3 (91%), followed by group 1 (72%) and group 2 (53%).<br />Conclusions: Results of this study suggested that osteoconductive bioabsorbable scaffolds prepared from PPF might be used as an autograft extender when applied as an adjunct to spinal fusion.
- Subjects :
- Animals
Lumbar Vertebrae anatomy & histology
Lumbar Vertebrae diagnostic imaging
Materials Testing
Microscopy, Electron, Scanning
Particle Size
Rabbits
Radiography
Bone Substitutes therapeutic use
Lumbar Vertebrae surgery
Polymers therapeutic use
Propylene Glycols therapeutic use
Spinal Fusion methods
Subjects
Details
- Language :
- English
- ISSN :
- 0940-6719
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 16133085
- Full Text :
- https://doi.org/10.1007/s00586-005-1001-8