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Angiotensin blockade in children with chronic glomerulonephritis and heavy proteinuria.
- Source :
-
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2005 Nov; Vol. 20 (11), pp. 1651-4. Date of Electronic Publication: 2005 Aug 16. - Publication Year :
- 2005
-
Abstract
- Patients with chronic proteinuric nephropathies are at high risk of developing progressive renal insufficiency. There are limited controlled data on the efficacy of potentially toxic immunosuppressive therapies for many of these diseases such as immunoglobulin A nephropathy and idiopathic membranoproliferative glomerulonephritis. This limitation has not deterred healthcare providers from using such agents based on anecdotal experience. We report our experience taking care of three children with heavy proteinuria from chronic glomerular diseases. All were treated with a combination of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers without concomitant immunosuppression. All went into complete remission soon after starting therapy, allowing corticosteroid avoidance. The purpose of this report is to make healthcare professionals more aware of the potential success that can be achieved with this relatively nontoxic drug regimen. Larger controlled clinical trials using this strategy are needed to better evaluate the efficacy and safety of this approach in children with glomerular diseases.
- Subjects :
- Child
Chronic Disease
Drug Therapy, Combination
Female
Glomerulonephritis etiology
Glomerulonephritis urine
Humans
Male
Remission Induction
Angiotensin II Type 1 Receptor Blockers administration & dosage
Angiotensin-Converting Enzyme Inhibitors administration & dosage
Glomerulonephritis drug therapy
Proteinuria complications
Subjects
Details
- Language :
- English
- ISSN :
- 0931-041X
- Volume :
- 20
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Pediatric nephrology (Berlin, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 16133038
- Full Text :
- https://doi.org/10.1007/s00467-005-2031-5