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Pursaethosides A-E, triterpene saponins from Entada pursaetha.
- Source :
-
Journal of natural products [J Nat Prod] 2005 Aug; Vol. 68 (8), pp. 1185-90. - Publication Year :
- 2005
-
Abstract
- Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the n-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
Cameroon
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Saponins chemistry
Saponins pharmacology
Triterpenes chemistry
Triterpenes pharmacology
Tumor Cells, Cultured
Antineoplastic Agents, Phytogenic isolation & purification
Mimosa chemistry
Plants, Medicinal chemistry
Saponins isolation & purification
Triterpenes isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 68
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 16124758
- Full Text :
- https://doi.org/10.1021/np0580311