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Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2005 Sep 06; Vol. 102 (36), pp. 12783-8. Date of Electronic Publication: 2005 Aug 25. - Publication Year :
- 2005
-
Abstract
- Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhibited phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.
- Subjects :
- Androstadienes pharmacology
Animals
Cell Line
Cell Nucleus genetics
Chlorocebus aethiops
Humans
Phosphatidylinositol 3-Kinases genetics
Phosphotransferases (Alcohol Group Acceptor) genetics
Protein Kinase Inhibitors pharmacology
RNA, Messenger genetics
Rats
Saccharomyces cerevisiae drug effects
Saccharomyces cerevisiae genetics
Saccharomyces cerevisiae metabolism
Transaminases genetics
Transaminases metabolism
Wortmannin
Cell Nucleus enzymology
Gene Expression Regulation
Phosphatidylinositol 3-Kinases metabolism
Phosphotransferases (Alcohol Group Acceptor) metabolism
Transcription, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 102
- Issue :
- 36
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 16123124
- Full Text :
- https://doi.org/10.1073/pnas.0506184102