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lipase-catalyzed regioselective esterification of rapamycin: synthesis of temsirolimus (CCI-779).
- Source :
-
Organic letters [Org Lett] 2005 Sep 01; Vol. 7 (18), pp. 3945-8. - Publication Year :
- 2005
-
Abstract
- A lipase-catalyzed acylation of the immunosuppressant rapamycin with complete regioselectivity is described. The method was successfully applied to the synthesis of 42-hemiesters and temsirolimus (CCI-779), an investigational oncology drug.[reaction: see text]
Details
- Language :
- English
- ISSN :
- 1523-7060
- Volume :
- 7
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 16119938
- Full Text :
- https://doi.org/10.1021/ol0514395