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Meiotic delay of mouse spermatocytes carrying x-ray-induced translocations.

Authors :
van Buul PP
Seelen CM
Goudzwaard JH
Source :
Cytogenetics and cell genetics [Cytogenet Cell Genet] 1992; Vol. 60 (2), pp. 146-9.
Publication Year :
1992

Abstract

The kinetics of spermatocyte progression through meiotic prophase in cells with or without induced translocations were studied in mice that had been exposed to x-rays. Pulse-labeling experiments using 3H-thymidine, followed by autoradiographic analysis, indicated that at higher x-ray doses (6 and 7 Gy), translocation-carrying cells tend to spend more time in meiotic prophase than do normal cells. At 2 Gy, no such delay seemed to be present. The observed delay may explain the reduction in transmission of translocations to the next generation reported by others.

Details

Language :
English
ISSN :
0301-0171
Volume :
60
Issue :
2
Database :
MEDLINE
Journal :
Cytogenetics and cell genetics
Publication Type :
Academic Journal
Accession number :
1611914
Full Text :
https://doi.org/10.1159/000133326