Back to Search
Start Over
Chronic morphine exposure induces degradation of receptive field properties of LGN cells in cats.
- Source :
-
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2005 Sep; Vol. 26 (9), pp. 1034-8. - Publication Year :
- 2005
-
Abstract
- Aim: To investigate the effect of chronic morphine exposure on the receptive field properties of lateral geniculate nucleus (LGN) neurons in cats.<br />Methods: Cats were injected with morphine (10 mg/kg) or saline twice daily, for 10 d. Subsequently, extracellular single-unit recording techniques were used to examine the sensitivity of LGN neurons to visual stimuli in chronic morphine-treated and saline-treated cats.<br />Results: Compared with saline-treated cats (as controls), LGN neurons in morphine-treated cats had decreased signal-to-noise ratios (1.9 vs 3.1), and orientation and direction sensitivity (0.103 vs 0.135 and 0.074 vs 0.10, respectively), accompanied by significant increases in spontaneous (27.4 vs 17.5) and evoked activity (preferred: 42.2 vs 38.1; average: 28.1 vs 22.3).<br />Conclusion: Chronic morphine exposure can lead to the functional degradation of LGN neurons in cats, which might result from the effects of chronic morphine exposure on inhibitory neurotransmission.
- Subjects :
- Action Potentials drug effects
Animals
Cats
Geniculate Bodies physiology
Male
Morphine administration & dosage
Narcotics administration & dosage
Neurons drug effects
Neurons physiology
Photic Stimulation
Geniculate Bodies drug effects
Morphine adverse effects
Narcotics adverse effects
Neural Inhibition drug effects
Orientation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1671-4083
- Volume :
- 26
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Acta pharmacologica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 16115367
- Full Text :
- https://doi.org/10.1111/j.1745-7254.2005.00190.x