Back to Search
Start Over
Indeterminate cell histiocytosis: fact or fiction?
- Source :
-
Journal of cutaneous pathology [J Cutan Pathol] 2005 Sep; Vol. 32 (8), pp. 552-60. - Publication Year :
- 2005
-
Abstract
- Indeterminate cell histiocytosis is a rare disorder, in which the predominant cells have the characteristics of both Langerhans cells and macrophages. We, in this study, describe 18 patients and compare them with those previously published. Most patients were adults with either solitary or multiple red-brown papules or nodules. While most lesions were confined to the skin, both conjunctival and bony involvement was seen. Histologically, the lesions showed patterns resembling those described for xanthogranulomas, with predominantly oncocytic (nine patients), spindled (five patients), scalloped (two patients) or vacuolated (two patients) macrophages. The accompanying infiltrate was mainly lymphocytic, although eosinophils and occasionally plasma cells were seen. All lesions were positive for macrophage markers, such as KP1 (CD68) and Ki-M1p, as well as for S-100 protein and showed variable reactivity for CD1a. No Birbeck granules were seen ultrastructurally in one patient. Some patients shared features with sinus histiocytosis with massive lymphadenopathy. It is unclear whether this disorder is a separate entity or represents various macrophage disorders identified at various time points in the inflammatory response. Ratzinger G, Burgdorf WHC, Metze D, Zelger BG, Zelger B. Indeterminate cell histiocytosis: fact or fiction? A clinicopathological series of 18 patients.
- Subjects :
- Adult
Aged
Biomarkers metabolism
Child
Child, Preschool
Female
Fluorescent Antibody Technique, Indirect
Histiocytosis metabolism
Humans
Immunoenzyme Techniques
Lymphocytes metabolism
Lymphocytes pathology
Macrophages metabolism
Macrophages pathology
Male
Middle Aged
Skin metabolism
Skin Diseases metabolism
Histiocytosis pathology
Skin pathology
Skin Diseases pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0303-6987
- Volume :
- 32
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of cutaneous pathology
- Publication Type :
- Academic Journal
- Accession number :
- 16115054
- Full Text :
- https://doi.org/10.1111/j.0303-6987.2005.00382.x