Back to Search
Start Over
Peripheral participation of the phosphodiesterase 3 on formalin-evoked nociception.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2005 Sep 05; Vol. 519 (1-2), pp. 75-9. - Publication Year :
- 2005
-
Abstract
- The local peripheral (subcutaneous) injection of phosphodiesterase 3 inhibitor trequinsin dose-dependently enhanced formalin-evoked flinching during late second phase of this test. Treatment with the nitric oxide synthase inhibitor N-L-nitro-arginine methyl ester or guanylyl cyclase inhibitor 1-H-[1,2,4,]oxadiazolo[4,3-a]quinoxalin-1-one significantly reversed trequinsin-induced pronociceptive effect. Results suggest that the peripheral phosphodiesterase 3 may play an important physiologic role on inflammatory pain by controlling cyclic AMP levels and therefore the nociceptor threshold.
- Subjects :
- 3',5'-Cyclic-AMP Phosphodiesterases antagonists & inhibitors
Animals
Cyclic Nucleotide Phosphodiesterases, Type 3
Dose-Response Relationship, Drug
Enzyme Inhibitors pharmacology
Female
Formaldehyde
Guanylate Cyclase antagonists & inhibitors
Injections, Subcutaneous
NG-Nitroarginine Methyl Ester pharmacology
Nitric Oxide Synthase antagonists & inhibitors
Oxadiazoles pharmacology
Pain chemically induced
Pain physiopathology
Pain Measurement methods
Quinoxalines pharmacology
Rats
Rats, Wistar
Tetrahydroisoquinolines pharmacology
Time Factors
3',5'-Cyclic-AMP Phosphodiesterases metabolism
Pain enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 519
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 16111678
- Full Text :
- https://doi.org/10.1016/j.ejphar.2005.06.048