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A polymorphism of the plasminogen activator inhibitor-1 gene promoter and the polycystic ovary syndrome.
- Source :
-
European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2005 Nov 01; Vol. 123 (1), pp. 77-81. Date of Electronic Publication: 2005 Aug 15. - Publication Year :
- 2005
-
Abstract
- Objective: To investigate the association of a common 5G/4G polymorphism of the plasminogen activator inhibitor-1 gene (PAI1) with occurrence and clinical characteristics of the polycystic ovary syndrome (PCOS).<br />Study Design: In a case-control study, we evaluated a series of 106 Caucasian women with PCOS and 102 healthy controls. Women completed a detailed questionnaire and underwent a peripheral venous puncture, ultrasonography, and a standardized oral glucose tolerance test (OGTT). The PAI1 gene promoter polymorphism was evaluated using PCR.<br />Results: Allele and genotype frequencies were not significantly different among women with PCOS and controls (P=0.3 and 0.6, respectively). In women with PCOS, presence of the 5G/4G polymorphism of PAI1 was not associated with changes in serum hormone levels or with clinical characteristics.<br />Conclusions: The 5G/4G polymorphism of the PAI1 promoter is not associated with occurrence and phenotype of the PCOS.
- Subjects :
- Adult
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Polycystic Ovary Syndrome etiology
Polymorphism, Single Nucleotide
Promoter Regions, Genetic genetics
White People genetics
Plasminogen Activator Inhibitor 1 genetics
Polycystic Ovary Syndrome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0301-2115
- Volume :
- 123
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of obstetrics, gynecology, and reproductive biology
- Publication Type :
- Academic Journal
- Accession number :
- 16102886
- Full Text :
- https://doi.org/10.1016/j.ejogrb.2005.07.002