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The integration of conventional and unconventional T cells that characterizes cell-mediated responses.

Authors :
Pennington DJ
Vermijlen D
Wise EL
Clarke SL
Tigelaar RE
Hayday AC
Source :
Advances in immunology [Adv Immunol] 2005; Vol. 87, pp. 27-59.
Publication Year :
2005

Abstract

This review builds on evidence that cell-mediated immune responses to bacteria, viruses, parasites, and tumors are an integration of conventional and unconventional T-cell activities. Whereas conventional T cells provide clonal antigen-specific responses, unconventional T cells profoundly regulate conventional T cells, often suppressing their activities such that immunopathology is limited. By extrapolation, immunopathologies and inflammatory diseases may reflect defects in regulation by unconventional T cells. To explore the function of unconventional T cells, several extensive gene expression analyses have been undertaken. These studies are reviewed in some detail, with emphasis on the mechanisms by which unconventional T cells may exert their regulatory functions. Highlighting the fundamental nature of T-cell integration, we also review emerging data that the development of conventional and unconventional T cells is also highly integrated.

Details

Language :
English
ISSN :
0065-2776
Volume :
87
Database :
MEDLINE
Journal :
Advances in immunology
Publication Type :
Academic Journal
Accession number :
16102571
Full Text :
https://doi.org/10.1016/S0065-2776(05)87002-6