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The integration of conventional and unconventional T cells that characterizes cell-mediated responses.
- Source :
-
Advances in immunology [Adv Immunol] 2005; Vol. 87, pp. 27-59. - Publication Year :
- 2005
-
Abstract
- This review builds on evidence that cell-mediated immune responses to bacteria, viruses, parasites, and tumors are an integration of conventional and unconventional T-cell activities. Whereas conventional T cells provide clonal antigen-specific responses, unconventional T cells profoundly regulate conventional T cells, often suppressing their activities such that immunopathology is limited. By extrapolation, immunopathologies and inflammatory diseases may reflect defects in regulation by unconventional T cells. To explore the function of unconventional T cells, several extensive gene expression analyses have been undertaken. These studies are reviewed in some detail, with emphasis on the mechanisms by which unconventional T cells may exert their regulatory functions. Highlighting the fundamental nature of T-cell integration, we also review emerging data that the development of conventional and unconventional T cells is also highly integrated.
- Subjects :
- Animals
Cell Adhesion Molecules genetics
Cell Adhesion Molecules metabolism
Chemokines genetics
Chemokines metabolism
Cytokines genetics
Cytokines metabolism
Cytotoxicity, Immunologic
Gene Expression Profiling
Humans
Killer Cells, Natural immunology
Mice
Models, Immunological
Receptors, Antigen, T-Cell, gamma-delta metabolism
Immunity, Cellular genetics
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0065-2776
- Volume :
- 87
- Database :
- MEDLINE
- Journal :
- Advances in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16102571
- Full Text :
- https://doi.org/10.1016/S0065-2776(05)87002-6