Effect of short-term treatment with pravastatin on cytokines and cytokine receptors in patients with chronic heart failure due to ischemic and nonischemic disease.

Authors :: Conraads VM
Bosmans JM
Schuerwegh AJ
De Clerck LS
Bridts CH
Wuyts FL
Stevens WJ
Vrints CJ
Source :: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2005 Aug; Vol. 24 (8), pp. 1114-7.
Publication Year :: 2005
Abstract: The antiinflammatory effect of lipoproteins through neutralization of circulating endotoxin has questioned the safety of lipid-lowering drugs in chronic heart failure (CHF). We measured serum levels of interleukin-6, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors 1 and 2 before and after 1-month treatment with pravastatin 40 mg in 58 patients with CHF. Short-term treatment with pravastatin attenuated the immune response in patients with CHF due to ischemic or nonischemic etiology.

Language :: English
ISSN :: 1053-2498
Volume :: 24
Issue :: 8
Database :: MEDLINE
Journal :: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Publication Type :: Academic Journal
Accession number :: 16102449
Full Text :: https://doi.org/10.1016/j.healun.2004.08.021

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