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A phase I study of moderate-dose radiation therapy and weekly gemcitabine in patients with locally advanced non-small cell lung cancer not suitable for radical chemoradiation therapy.
- Source :
-
Clinical oncology (Royal College of Radiologists (Great Britain)) [Clin Oncol (R Coll Radiol)] 2005 Aug; Vol. 17 (5), pp. 332-6. - Publication Year :
- 2005
-
Abstract
- Aims: To describe the toxicity and response seen in patients receiving moderate-dose radiation therapy with concurrent weekly low-dose gemcitabine in the management of locally advanced non-small cell lung cancer (NSCLC).<br />Materials and Methods: Eighteen patients with confirmed NSCLC were enrolled over a 17-month period from August 2000 until January 2002. All had localised disease but were considered unsuitable for curative therapy. Radiation therapy was given to a dose of 30 Gy in 15 fractions over 3 weeks. Gemcitabine was given weekly before and within 3 h of fractions 1, 6 and 11. The study was designed as a dose-escalation study, commencing at 100 mg/m2 and increasing at levels of 50 mg/m2, until the maximum tolerated dose (MTD) was reached.<br />Results: The MTD was regarded as being 150 mg/m2. The major acute toxicity observed was oesophagitis. Skin reactions were also reported. The overall response rate in all patients was 88%, with 44% achieving a complete response.<br />Conclusion: The combination of gemcitabine and moderate-dose radiation therapy is feasible, and offers low toxicity and excellent response rates in patients with localised NSCLC not suitable for high-dose therapy.
- Subjects :
- Adult
Aged
Humans
Male
Maximum Tolerated Dose
Middle Aged
Radiation Pneumonitis etiology
Radiotherapy adverse effects
Radiotherapy Dosage
Time Factors
Gemcitabine
Carcinoma, Non-Small-Cell Lung radiotherapy
Deoxycytidine administration & dosage
Deoxycytidine analogs & derivatives
Lung Neoplasms radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 0936-6555
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical oncology (Royal College of Radiologists (Great Britain))
- Publication Type :
- Academic Journal
- Accession number :
- 16097563
- Full Text :
- https://doi.org/10.1016/j.clon.2005.03.013