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Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 model.
- Source :
-
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2006 Jan; Vol. 16 (1), pp. 59-69. Date of Electronic Publication: 2005 Aug 10. - Publication Year :
- 2006
-
Abstract
- With increasing knowledge of molecular, biochemical and cellular events causing synaptic dysfunction and neurodegeneration in Alzheimer-diseased brain, preventive treatment strategies are emerging. Neuroprotective capacities have been attributed to galantamine and memantine. The age-dependent cognitive decline in the APP23 model was employed to evaluate disease-modifying efficacy of chronic treatment with both compounds. At age 6 weeks, heterozygous APP23 mice were subcutaneously implanted with osmotic pumps delivering saline, galantamine (1.3 or 2.6 mg/kg/day) or memantine (7.2 or 14.4 mg/kg/day). After 2 months of treatment, a 3-week wash-out period was allowed to prevent bias from sustained symptomatic effects. Subsequently, cognitive evaluation in the Morris water maze commenced. Galantamine low dose significantly improved spatial accuracy during probe trial. Memantine improved acquisition performance (path length) and spatial accuracy during probe trial in a dose-dependent manner. This is the first study reporting disease-modifying efficacy of galantamine and memantine in transgenic mice modeling Alzheimer's disease.
- Subjects :
- Amyloid beta-Protein Precursor genetics
Analysis of Variance
Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Delivery Systems
Humans
Maze Learning drug effects
Mice
Mice, Transgenic
Motor Activity drug effects
Neuropsychological Tests statistics & numerical data
Random Allocation
Reaction Time drug effects
Time Factors
Alzheimer Disease drug therapy
Cholinesterase Inhibitors therapeutic use
Cognition drug effects
Excitatory Amino Acid Antagonists therapeutic use
Galantamine therapeutic use
Memantine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0924-977X
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 16095884
- Full Text :
- https://doi.org/10.1016/j.euroneuro.2005.06.005