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Colorectal cancer: mutations in a signalling pathway.
- Source :
-
Nature [Nature] 2005 Aug 11; Vol. 436 (7052), pp. 792. - Publication Year :
- 2005
-
Abstract
- Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.
- Subjects :
- Colorectal Neoplasms metabolism
DNA Mutational Analysis
Exons genetics
Humans
Phosphatidylinositol 3-Kinases metabolism
Polymerase Chain Reaction
Protein Serine-Threonine Kinases chemistry
Protein Serine-Threonine Kinases genetics
Protein Serine-Threonine Kinases metabolism
Protein Structure, Tertiary genetics
Colorectal Neoplasms enzymology
Colorectal Neoplasms genetics
Mutation genetics
Signal Transduction genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 436
- Issue :
- 7052
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 16094359
- Full Text :
- https://doi.org/10.1038/436792a