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[Effects of low molecular weight heparin on vascular endothelial growth factor expression of early diabetic nephropathy].
- Source :
-
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2005 Aug 18; Vol. 37 (4), pp. 382-5. - Publication Year :
- 2005
-
Abstract
- Objective: To investigate the effects of low molecular weight heparin (LMWH) on vascular endothelial growth factor (VEGF) expression of early diabetic nephropathy.<br />Methods: Ninety-five male SD rats were randomly divided into three groups: normal control rats, STZ-induced diabetic rats and diabetic rats treated with LMWH. The renal tissues were subjected to immunohistochemical staining after 1, 2, 4, 6, and 8 weeks' treatment respectively to quantify the VEGF expression.<br />Results: Immunohistochemical staining demonstrated an increasing in VEGF positive cells in diabetic rats. It was found that there were significant differences in VEGF staining intensity between diabetic rats and normal control rats and between LMWH treated rats and untreated diabetic rats after two weeks treatment.<br />Conclusion: The inhibition of VEGF expression may be one of the mechanisms of LMWH's renal protective effects on early diabetic nephropathy.
- Subjects :
- Animals
Diabetes Mellitus, Experimental complications
Diabetes Mellitus, Experimental drug therapy
Heparin, Low-Molecular-Weight pharmacology
Male
Random Allocation
Rats
Rats, Sprague-Dawley
Vascular Endothelial Growth Factor A genetics
Diabetic Nephropathies drug therapy
Diabetic Nephropathies metabolism
Heparin, Low-Molecular-Weight therapeutic use
Vascular Endothelial Growth Factor A biosynthesis
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1671-167X
- Volume :
- 37
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
- Publication Type :
- Academic Journal
- Accession number :
- 16086057