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Preimplantation genetic diagnosis reduces pregnancy loss in women aged 35 years and older with a history of recurrent miscarriages.
- Source :
-
Fertility and sterility [Fertil Steril] 2005 Aug; Vol. 84 (2), pp. 331-5. - Publication Year :
- 2005
-
Abstract
- Objective: To determine whether preimplantation genetic diagnosis (PGD) and transfer of euploid embryos would decrease spontaneous abortion rates in recurrent miscarriage (RM) patients.<br />Design: Controlled clinical study.<br />Setting: In vitro fertilization centers and PGD reference laboratory.<br />Patient(s): Recurrent-miscarriage patients with three or more prior lost pregnancies with no known etiology.<br />Intervention(s): Biopsy of a single blastomere from each day 3 embryo, followed by fluorescence in situ hybridization analysis.<br />Main Outcome Measure(s): The rate of spontaneous abortions in RM subjects undergoing PGD were compared with [1] their own a priori expectations and [2] a comparison group of women undergoing PGD for advanced maternal age (> or =35 years).<br />Result(s): Before PGD, RM patients had lost 87% (262/301) of their pregnancies, with an expected loss rate of 36.5%. After, they only lost 16.7% pregnancies. This difference was mostly due to reduction in pregnancy loss in the > or =35-years age subgroup, to 12% from an expected 44.5%.<br />Conclusion(s): Preimplantation genetic diagnosis aneuploidy screening has a beneficial effect on pregnancy outcome in RM couples, especially those in which the woman is aged > or =35 years. Our data indicate that PGD reduces the risk of miscarriage in RM patients to baseline levels.
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 84
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 16084873
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2005.02.027