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Galactose-carrying polymers as extracellular matrices for liver tissue engineering.
- Source :
-
Biomaterials [Biomaterials] 2006 Feb; Vol. 27 (4), pp. 576-85. Date of Electronic Publication: 2005 Aug 08. - Publication Year :
- 2006
-
Abstract
- Extracellular matrix (ECM) plays important roles in tissue engineering because cellular growth and differentiation, in the two-dimensional cell culture as well as in the three-dimensional space of the developing organism, require ECM with which the cells can interact. Especially, the bioartificial liver-assist device or regeneration of the liver-tissue substitutes for liver tissue engineering requires a suitable ECM for hepatocyte culture because hepatocytes are anchorage-dependent cells and are highly sensitive to the ECM milieu for the maintenance of their viability and differentiated functions. Galactose-carrying synthetic ECMs derived from synthetic polymers and natural polymers bind hepatocytes through a receptor-mediated mechanism, resulting in enhanced hepatocyte functions. Attachment and functions of hepatocytes were affected by physico-chemical properties including ECM geometry as well as the type, density and orientation of galactose. Also, cellular environment, medium composition and dynamic culture system influenced liver-specific functions of hepatocytes beside ECM.
- Subjects :
- Animals
Biocompatible Materials chemistry
Cell Culture Techniques instrumentation
Cell Culture Techniques methods
Cell Proliferation
Hepatocytes cytology
Humans
Tissue Engineering instrumentation
Extracellular Matrix chemistry
Galactose chemistry
Hepatocytes physiology
Liver growth & development
Liver, Artificial
Polymers chemistry
Tissue Engineering methods
Subjects
Details
- Language :
- English
- ISSN :
- 0142-9612
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 16084586
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2005.06.008