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alpha2-Adrenergic agonists antagonise the anxiolytic-like effect of antidepressants in the four-plate test in mice.
- Source :
-
Behavioural brain research [Behav Brain Res] 2005 Oct 14; Vol. 164 (1), pp. 17-28. - Publication Year :
- 2005
-
Abstract
- Selective serotonin reuptake inhibitors (SSRIs) and serotonin/noradrenaline reuptake inhibitors (SNRIs) has been reported to be efficient in anxiety disorders. Some animal models have demonstrated an anxiolytic-like effect following acute administration, however, it is not yet known how noradrenergic receptors are implicated in the therapeutic effects of antidepressants (ADs) in anxiety. The effects of two alpha(2)-adrenoceptor agonists (clonidine, guanabenz) on anxiolytic-like effect of two SSRIs (paroxetine and citalopram) and two SNRIs (venlafaxine and milnacipran) were evaluated in the four-plate test (FPT) in mice. Paroxetine (4 mg/kg), citalopram (8 mg/kg), venlafaxine (8 mg/kg), and milnacipran (8 mg/kg) administered intraperitoneally (i.p.) increased the number of punishments accepted by mice in the FPT. Clonidine (0.0039-0.5 mg/kg) and guanabenz (0.03-0.5mg/kg) had no effect on the number of punishments accepted by mice. Clonidine (0.03 and 0.06 mg/kg) and guanabenz (0.125 and 0.5 mg/kg) (i.p. -45 min) reversed the anti-punishment effect of paroxetine, citalopram, venlafaxine and milnacipran (i.p. -30 min). But if the antidepressants are administered 45 min before the test and alpha(2)-adrenoceptor agonists 30 min before the test, alpha(2)-adrenoceptor agonists failed to alter the anti-punishment effect of antidepressants. The results of this present study indicate that alpha(2)-adrenoceptor agonists antagonise the anxiolytic-like effect of antidepressants in mice when they are administered 15 min before the administration of antidepressant suggesting a close inter-regulation between noradrenergic and serotoninergic system in the mechanism of SSRIs and SNRIs in anxiety-like behaviour.
- Subjects :
- Adrenergic Uptake Inhibitors antagonists & inhibitors
Animals
Anti-Anxiety Agents antagonists & inhibitors
Citalopram antagonists & inhibitors
Citalopram pharmacology
Clonidine pharmacology
Cyclohexanols antagonists & inhibitors
Cyclohexanols pharmacology
Cyclopropanes antagonists & inhibitors
Cyclopropanes pharmacology
Dose-Response Relationship, Drug
Drug Antagonism
Guanabenz pharmacology
Male
Mice
Milnacipran
Motor Activity drug effects
Paroxetine antagonists & inhibitors
Paroxetine pharmacology
Punishment
Selective Serotonin Reuptake Inhibitors antagonists & inhibitors
Statistics, Nonparametric
Venlafaxine Hydrochloride
Adrenergic Uptake Inhibitors pharmacology
Adrenergic alpha-Agonists pharmacology
Anti-Anxiety Agents pharmacology
Antidepressive Agents pharmacology
Anxiety drug therapy
Selective Serotonin Reuptake Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0166-4328
- Volume :
- 164
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 16081166
- Full Text :
- https://doi.org/10.1016/j.bbr.2005.05.017