Back to Search
Start Over
Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2005 Aug 22; Vol. 518 (2-3), pp. 221-6. - Publication Year :
- 2005
-
Abstract
- Here we show the increased hepatocyte growth factor (HGF) and cyclooxygenase-2 (COX-2) expression in gastric mucosa of rats which have developed a reserpine-induced ulcer. Such an increase of HGF and COX-2 expression was blunted in rats pretreated with adrenomedullin. Pretreatment with adrenomedullin and the adrenomedullin22-52 fragment did not result in changes of HGF and COX-2 expression, compared to the reserpine and adrenomedullin treated group. Pretreatment with adrenomedullin and the calcitonin gene-related peptide8-37 fragment (CGRP8-37) increased HGF and COX-2 expression, compared to the reserpine and adrenomedullin treated group. Our results suggest that the inhibitory effect of adrenomedullin on the expression of HGF and COX-2 is mediated by CGRP receptors.
- Subjects :
- Adrenomedullin
Analysis of Variance
Animals
Blotting, Western
Calcitonin Gene-Related Peptide pharmacology
Cyclooxygenase 2
Gastric Mucosa metabolism
Gastric Mucosa pathology
Immunohistochemistry
Male
Peptide Fragments pharmacology
Rats
Rats, Sprague-Dawley
Gastric Mucosa drug effects
Hepatocyte Growth Factor biosynthesis
Peptides pharmacology
Prostaglandin-Endoperoxide Synthases biosynthesis
Reserpine toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 518
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 16081063
- Full Text :
- https://doi.org/10.1016/j.ejphar.2005.06.001