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Evaluation of Strychnos pseudoquina ST. HIL. leaves extract on gastrointestinal activity in mice.
- Source :
-
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2005 Aug; Vol. 53 (8), pp. 881-5. - Publication Year :
- 2005
-
Abstract
- Strychnos pseudoquina ST. HIL. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects.
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal antagonists & inhibitors
Drug Evaluation, Preclinical
Gastric Mucosa pathology
Mice
Stomach Ulcer chemically induced
Stomach Ulcer prevention & control
Gastric Mucosa drug effects
Plant Extracts pharmacology
Plant Leaves chemistry
Strychnos chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0009-2363
- Volume :
- 53
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Chemical & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 16079513
- Full Text :
- https://doi.org/10.1248/cpb.53.881