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Effect of levodopa on pain threshold in Parkinson's disease: a clinical and positron emission tomography study.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2005 Dec; Vol. 20 (12), pp. 1557-63. - Publication Year :
- 2005
-
Abstract
- Patients suffering from Parkinson's disease (PD) frequently experienced painful sensations that could be in part due to central modification of nociception. We compared pain threshold before and after administration of levodopa in PD patients and in controls, and investigated cerebral activity with positron emission tomography (PET) during experimental nociceptive stimulation. Pain threshold was determined using thermal stimulation during two randomized conditions: off and on. We performed H(2) (15)O PET analysis of regional cerebral blood flow on subjects while they received alternate randomized noxious and innocuous stimuli during off and on conditions. In off condition, pain threshold in nine PD patients was significantly lower than in nine controls. Administration of levodopa significantly raised pain threshold in PD patients but not in controls. During off condition, there was a significant increase in pain-induced activation in right insula and prefrontal and left anterior cingulate cortices in PD compared to control group. Levodopa significantly reduced pain-induced activation in these areas in PD. This study shows that pain threshold is lower in PD patients but returns to normal ranges after levodopa administration. Moreover, PD patients have higher pain-induced activation in nociceptive pathways, which can be reduced by levodopa.
- Subjects :
- Aged
Brain Mapping
Case-Control Studies
Cerebral Cortex blood supply
Cerebrovascular Circulation drug effects
Humans
Middle Aged
Pain drug therapy
Pain etiology
Pain Clinics
Pain Measurement methods
Parkinson Disease physiopathology
Antiparkinson Agents therapeutic use
Levodopa therapeutic use
Pain Threshold drug effects
Parkinson Disease drug therapy
Positron-Emission Tomography
Subjects
Details
- Language :
- English
- ISSN :
- 0885-3185
- Volume :
- 20
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 16078219
- Full Text :
- https://doi.org/10.1002/mds.20629