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Evidence for the conservation of an immunoreactive monokine network in invertebrates.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 1992 Apr 15; Vol. 650, pp. 74-80. - Publication Year :
- 1992
-
Abstract
- Mytilus edulis, a marine bivalve mollusc, contains hemocytes that share certain properties with cells of the human monocyte-macrophage lineage. Because of this and previously reported similar responses to opioids between Mytilus hemocytes and human granulocytes, we determined whether Mytilus might also possess monokines or an immune monokine-like network. We chose to study two monokines, interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF). We found that Mytilus hemocytes respond to recombinant human IL-1 and TNF in a fashion similar to human granulocytes. Furthermore, we show that as in the human system, it appears that IL-1 mediates at least part of its effects through immunoreactive (ir) TNF in Mytilus. Finally, we show that Mytilus hemolymph contains ir IL-1 and TNF. To our knowledge, this is the first demonstration of these substances in this system.
Details
- Language :
- English
- ISSN :
- 0077-8923
- Volume :
- 650
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 1605500
- Full Text :
- https://doi.org/10.1111/j.1749-6632.1992.tb49098.x