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Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II.
- Source :
-
The Journal of nutrition [J Nutr] 2005 Aug; Vol. 135 (8), pp. 1836-40. - Publication Year :
- 2005
-
Abstract
- Hyperhomocysteinemia (HH) constitutes a risk marker for thrombosis, but the pathophysiological mechanisms in thrombus formation are still unresolved. We investigated the influence of HH on single coagulation factor functions and evaluated the platelet GpIIb/IIIa receptor function in HH-induced changes in whole-blood coagulation profiles (WBCP). Three groups of 12 rats were investigated: control rats, folate deficient-HH (FD-HH) rats, and treated rats. Plasma total homocysteine was 7.1 micromol/L in controls, 31.3 micromol/L in FD-HH rats, and 7.6 micromol/L in treated rats. Factor (F) II:C, FX:C, and FXII:C were reduced in FD-HH rats compared with controls and normalized in treated rats (P < 0.05). FVII:C activity did not differ among the groups. Factor VIII:C activity was greater in FD-HH rats than in controls (P < 0.05). Blockage of the platelet GpIIb/IIIa receptor by Integrilin (Schering-Plough A/S) did not abolish the FD-HH-induced increase in whole-blood coagulation velocity, irrespective of the dosage of Integrilin. In conclusion, FD-HH reduced the functional activities of FXII:C, FX:C and FII:C, whereas FVII:C was unchanged and FVIII:C increased. These findings may partially explain the prolonged initiation phase of WBCP in FD-HH rats. The changes in single coagulation factor functions and WBCPs in FD-HH rats were reversed by treatment with folic acid.
- Subjects :
- Animals
Dietary Supplements
Disease Models, Animal
Factor X drug effects
Factor XII drug effects
Folic Acid administration & dosage
Folic Acid Deficiency
Male
Prothrombin drug effects
Rats
Rats, Inbred WKY
Factor X metabolism
Factor XII metabolism
Folic Acid pharmacology
Hyperhomocysteinemia chemically induced
Prothrombin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3166
- Volume :
- 135
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 16046705
- Full Text :
- https://doi.org/10.1093/jn/135.8.1836