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[Cut-off level of docetaxel, paclitaxel and gemcitabine in histoculture drug response assay for non-small cell lung cancer].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2005 Jul; Vol. 32 (7), pp. 1013-6. - Publication Year :
- 2005
-
Abstract
- Cut-off levels of docetaxel (DOC), paclitaxel (PAC), and gemcitabine (GEM) in histoculture drug response assay are determined by data acquisition of non-small cell lung cancer. Inhibition rates were 47.5 +/- 22.2% in DOC (n=181), 66.6 +/- 25.1% in PAC (n=57), and 25.4 +/- 18.4% in GEM (n=63), respectively. Cut-off levels were determined as 50% in DOC, 60% in PAC, and 30% in GEM. The positive rates such as 47.5% in DOC, 68.4% in PAC, and 33.3% in GEM were obtained.
- Subjects :
- Adult
Aged
Docetaxel
Drug Screening Assays, Antitumor
Female
Humans
Male
Middle Aged
Tumor Cells, Cultured
Gemcitabine
Antineoplastic Agents, Phytogenic pharmacology
Carcinoma, Non-Small-Cell Lung pathology
Deoxycytidine analogs & derivatives
Deoxycytidine pharmacology
Lung Neoplasms pathology
Paclitaxel pharmacology
Taxoids pharmacology
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 32
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 16044964