Back to Search
Start Over
PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.
- Source :
-
Journal of molecular evolution [J Mol Evol] 2005 Sep; Vol. 61 (3), pp. 372-80. Date of Electronic Publication: 2005 Jul 21. - Publication Year :
- 2005
-
Abstract
- An emerging series of papers has identified new receptor proteins that predict seven-transmembrane pass topologies. We have consolidated this family to 11 human genes and have named the family PAQR, after two of the initially described ligands (progestin and adipoQ receptors). This protein family has ancient evolutionary roots, with identified homologs found in eubacteria. To date, published data indicate that the prokaryotic members of this family appear to encode hemolysin-type proteins, while in eukaryotes, PAQR proteins encode functional receptors with a broad range of apparent ligand specificities. We provide the complete human and mouse complement of this family, suggest a conserved structure/topology with invariant intracellular amino acid residues, and have measured mRNA expression levels for these genes across a range of human tissues.
- Subjects :
- Amino Acid Sequence
Animals
Evolution, Molecular
Humans
Mice
Molecular Sequence Data
Phylogeny
RNA, Messenger analysis
RNA, Messenger genetics
Receptors, Cell Surface genetics
Receptors, Cell Surface metabolism
Sequence Alignment
Sequence Homology, Amino Acid
Cell Membrane metabolism
Receptors, Cell Surface chemistry
Receptors, Cell Surface classification
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2844
- Volume :
- 61
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of molecular evolution
- Publication Type :
- Academic Journal
- Accession number :
- 16044242
- Full Text :
- https://doi.org/10.1007/s00239-004-0375-2