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Polymorphisms in the DBH and DRD2 gene regions and smoking behavior.
- Source :
-
European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2006 Mar; Vol. 256 (2), pp. 93-7. Date of Electronic Publication: 2005 Jul 21. - Publication Year :
- 2006
-
Abstract
- The DRD2 TaqI A and DBH-1021 C/T polymorphisms were genotyped in smoking alcoholics (N = 100), non-alcoholic smokers (N = 120) and nonsmoking controls (N = 112). Alcoholic and non-alcoholic smokers presented a higher frequency of the DRD2 TaqI A1 allele (P = 0.04) than non-smoking controls. Individuals who had at least one DBH-1021 T allele smoked fewer cigarettes per day than CC homozygotes (P = 0.03). These results are coherent with the expected effects of these polymorphisms on dopaminergic function.
- Subjects :
- Adult
Alcoholism genetics
Alleles
Chromosomes, Human, Pair 11 genetics
Chromosomes, Human, Pair 9 genetics
Comorbidity
Gene Frequency
Genotype
Homozygote
Humans
Male
Polymerase Chain Reaction
Taq Polymerase genetics
Dopamine beta-Hydroxylase genetics
Polymorphism, Genetic genetics
Receptors, Dopamine D2 genetics
Smoking genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0940-1334
- Volume :
- 256
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European archives of psychiatry and clinical neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 16032443
- Full Text :
- https://doi.org/10.1007/s00406-005-0610-x