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Cognitive performance of patients with mesial temporal lobe epilepsy and incidental calcified neurocysticercosis.

Authors :
Terra-Bustamante VC
Coimbra ER
Rezek KO
Escorsi-Rosset SR
Guarnieri R
Dalmagro CL
Inuzuka LM
Bianchin MM
Wichert-Ana L
Alexandre V
Takayanagui OM
Araújo D
dos Santos AC
Carlotti CG
Walz R
Markowitsch HJ
Sakamoto AC
Source :
Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2005 Aug; Vol. 76 (8), pp. 1080-3.
Publication Year :
2005

Abstract

Objectives: Although chronic calcified neurocysticercosis (NCC) has been considered a major cause of symptomatic epilepsy in developing countries, it can also be an incidental pathological finding in epileptic patients from endemic regions. The mechanisms of brain plasticity occurring in patients with NCC during and after the inflammatory process related to the parasite infection, death, degeneration, and calcification within the host brain might be an independent factor for cognitive impairment in patients with NCC and epilepsy. In order to assess this possibility cognitive performance of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) with and without NCC was investigated through structured neuropsychological testing.<br />Methods: Cognitive performance of long term MTLE-HS patients with (HS-NCC group, n = 32) and without NCC (HS only, n = 48) was compared. Imbalances between the two groups with respect to clinical, demographic, neuroimaging, and electrophysiological variables were adjusted by linear multiple regression analysis and Bonferroni correction for multiple tests.<br />Results and Conclusions: There were no cognitive performance differences between HS-NCC and HS only patients, leading to the conclusion that chronic calcified NCC per se does not aggravate the cognitive performance of patients with long term MTLE-HS.

Details

Language :
English
ISSN :
0022-3050
Volume :
76
Issue :
8
Database :
MEDLINE
Journal :
Journal of neurology, neurosurgery, and psychiatry
Publication Type :
Academic Journal
Accession number :
16024883
Full Text :
https://doi.org/10.1136/jnnp.2004.048934