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A relapsing inflammatory syndrome and active human herpesvirus 8 infection.
- Source :
-
The New England journal of medicine [N Engl J Med] 2005 Jul 14; Vol. 353 (2), pp. 156-63. - Publication Year :
- 2005
-
Abstract
- We describe an immunocompetent 61-year-old woman who was negative for human immunodeficiency virus and who had recurrent human herpesvirus 8 (HHV-8) infection associated with a relapsing systemic inflammatory syndrome characterized by fever, lymphadenopathy, splenomegaly, edema, arthrosynovitis, and rash. Kaposi's sarcoma developed 10 months after the initial clinical presentation. A correlation was documented between the recurrent clinical manifestations and the HHV-8 load in plasma and peripheral-blood mononuclear cells. Histologic examination of an enlarged lymph node heavily infected with HHV-8 revealed an atypical lymphoproliferative disorder characterized by paracortical hyperplasia and collapsed primary and secondary follicles.<br /> (Copyright 2005 Massachusetts Medical Society)
- Subjects :
- DNA, Viral blood
Edema virology
Exanthema virology
Female
HIV Seronegativity
Humans
Immunocompetence
Lymph Nodes pathology
Lymph Nodes virology
Middle Aged
Recurrence
Sarcoma, Kaposi complications
Splenomegaly virology
Viral Load
Arthritis virology
Herpesviridae Infections complications
Herpesvirus 8, Human isolation & purification
Lymphatic Diseases virology
Synovitis virology
Subjects
Details
- Language :
- English
- ISSN :
- 1533-4406
- Volume :
- 353
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The New England journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 16014885
- Full Text :
- https://doi.org/10.1056/NEJMoa042850