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Long-term effects of constant light or darkness on chicken pineal hydroxyindole-O-methyltransferase expression: biochemical and cellular aspects.
- Source :
-
Cellular and molecular neurobiology [Cell Mol Neurobiol] 1992 Apr; Vol. 12 (2), pp. 177-84. - Publication Year :
- 1992
-
Abstract
- 1. Chickens kept in constant light, as opposed to constant darkness, display a twofold increase in the activity of pineal hydroxyindole-O-methyltransferase (HIOMT), the last acting enzyme in the melatonin pathway. 2. Using an immunological approach, we presently show that this regulation of HIOMT activity reflects changes in the concentration of a single molecular form of the enzyme protein (a 38 kDa polypeptide). Immunohistofluorescence indicates that these concentration changes concurrently affect modified photoreceptors and pinealocyte-like cells in the chicken pineal organ. 3. Together, the present data support the hypothesis that environmental lighting might regulate the expression of the HIOMT gene.
- Subjects :
- Acetylserotonin O-Methyltransferase genetics
Animals
Circadian Rhythm
Darkness
Enzyme Induction radiation effects
Melatonin biosynthesis
Photoreceptor Cells enzymology
Photoreceptor Cells radiation effects
Pineal Gland cytology
Pineal Gland enzymology
Acetylserotonin O-Methyltransferase biosynthesis
Chickens physiology
Light
Pineal Gland radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 0272-4340
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cellular and molecular neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 1600555
- Full Text :
- https://doi.org/10.1007/BF00713371