Back to Search
Start Over
Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study.
- Source :
-
Atherosclerosis [Atherosclerosis] 2006 Mar; Vol. 185 (1), pp. 210-8. Date of Electronic Publication: 2005 Jul 07. - Publication Year :
- 2006
-
Abstract
- Plasma lipid profile is affected by endogenous estrogen levels and hormone replacement therapy (HRT). As plasma lipid concentrations have a significant heritable basis and the effects of both endogenous estrogen and use of HRT are mediated by estrogen receptors, we sought to investigate the relationships between polymorphisms in estrogen receptor-alpha (ESR1) and plasma lipid and lipoprotein concentrations. We analyzed data from 854 women (mean age 52+/-10 years) from the Framingham Heart Study. A TA repeat in the promoter region, c.30T>C in exon 1, c.454-397T>C, and c.454-351A>G in intron 1, all in linkage disequilibrium (LD), were significantly associated with low-density lipoprotein (LDL) particle size and concentration of small LDL particles. Women with the c.454-397C allele had larger LDL particle size (21.09+/-0.02 nm versus 21.01+/-0.03 nm, p=0.021) concurrent with lower small LDL particle concentration (0.47+/-0.02 mmol/L versus 0.58+/-0.03 mmol/L, p=0.008). Moreover, the TA[L]-c.30C-c.454-397C-c.454-351G haplotype (frequency, 32%) was associated with lower small LDL particle concentrations (-0.06+/-0.03 mmol/L change associated with each copy of this haplotype, p=0.011) when compared to the TA[S]-c.30T-c.454-397T-c.454-351A haplotype (frequency, 46%), where L and S are long and short TA repeats. Our results suggest that common ESR1 polymorphisms have a significant effect on lipoprotein metabolism in women.
- Subjects :
- Alleles
Estrogen Receptor alpha blood
Female
Gene Frequency
Genetic Markers
Haplotypes
Heart Diseases blood
Humans
Linkage Disequilibrium
Magnetic Resonance Spectroscopy
Menopause blood
Middle Aged
Polymerase Chain Reaction
DNA genetics
Estrogen Receptor alpha genetics
Heart Diseases genetics
Lipoproteins, LDL blood
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9150
- Volume :
- 185
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 16005459
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2005.06.008