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Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway.
- Source :
-
Neuron [Neuron] 2005 Jul 07; Vol. 47 (1), pp. 43-56. - Publication Year :
- 2005
-
Abstract
- During regional patterning of the anterior neural plate, a medially positioned domain of cells is specified to adopt retinal identity. These eye field cells remain coherent as they undergo morphogenetic events distinct from other prospective forebrain domains. We show that two branches of the Wnt signaling pathway coordinate cell fate determination with cell behavior during eye field formation. Wnt/beta-catenin signaling antagonizes eye specification through the activity of Wnt8b and Fz8a. In contrast, Wnt11 and Fz5 promote eye field development, at least in part, through local antagonism of Wnt/beta-catenin signaling. Additionally, Wnt11 regulates the behavior of eye field cells, promoting their cohesion. Together, these results allow us to postulate a model in which Wnt11 and Fz5 signaling promotes early eye development through the coordinated antagonism of signals that suppress retinal identity and promotion of coherence of eye field cells.
- Subjects :
- Animals
Brain embryology
Brain growth & development
Cell Movement physiology
Cell Transplantation
Cloning, Molecular
Diencephalon embryology
Diencephalon growth & development
Diencephalon physiology
Eye embryology
Frizzled Receptors
In Situ Hybridization
Lithium Chloride pharmacology
RNA, Messenger biosynthesis
RNA, Messenger genetics
Receptors, G-Protein-Coupled
Visual Fields physiology
Wnt Proteins
Zebrafish
beta Catenin
Cytoskeletal Proteins genetics
Cytoskeletal Proteins physiology
Eye growth & development
Glycoproteins genetics
Glycoproteins physiology
Signal Transduction genetics
Signal Transduction physiology
Trans-Activators genetics
Trans-Activators physiology
Zebrafish Proteins genetics
Zebrafish Proteins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0896-6273
- Volume :
- 47
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 15996547
- Full Text :
- https://doi.org/10.1016/j.neuron.2005.05.026