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Molecular diversity of HIV in Albania.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2005 Aug 01; Vol. 192 (3), pp. 475-9. Date of Electronic Publication: 2005 Jun 24. - Publication Year :
- 2005
-
Abstract
- Little information is available on circulating human immunodeficiency virus (HIV) subtypes and resistance to antiretroviral drugs in Albania. To fill this gap, we studied 72 plasma samples from HIV-infected individuals from throughout the country. Subtype classification and genotypic resistance analysis were performed on the HIV pol gene region. The analysis was successfully performed on 66 (91.6%) plasma samples and showed that 43 (65.2%) strains were non-B subtypes (mostly subtype A, as determined by analysis of pol gene sequences). No major mutations in the protease gene were found, whereas analysis of the reverse transcriptase gene revealed a few major mutations associated with resistance. In conclusion, non-B subtypes are predominant in Albania, and the prevalence of resistance to antiretroviral drugs is still low.
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 192
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 15995961
- Full Text :
- https://doi.org/10.1086/431599