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2-Aminoquinazoline inhibitors of cyclin-dependent kinases.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Sep 01; Vol. 15 (17), pp. 3881-5. - Publication Year :
- 2005
-
Abstract
- The inhibition of cyclin-dependent kinase 4 (Cdk4) causes cell cycle arrest and restores a checkpoint that is absent in the majority of tumor cells. Compounds that inhibit Cdk4 selectively are targeted for treating cancer. Appropriate substitution of 2-aminoquinazolines is demonstrated to produce high levels of selectivity for Cdk4 versus closely related serine-threonine kinases.
- Subjects :
- Antineoplastic Agents pharmacology
Cyclin-Dependent Kinase 4
Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors pharmacology
Humans
Inhibitory Concentration 50
Quinazolines pharmacology
Structure-Activity Relationship
Antineoplastic Agents chemical synthesis
Cyclin-Dependent Kinases antagonists & inhibitors
Proto-Oncogene Proteins antagonists & inhibitors
Quinazolines chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 15
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15993068
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.05.131