Back to Search
Start Over
Transient ischaemia refractory to conventional medical treatment in unstable angina: angiographic correlates and prognostic implications.
Transient ischaemia refractory to conventional medical treatment in unstable angina: angiographic correlates and prognostic implications.
- Source :
-
European heart journal [Eur Heart J] 1992 Mar; Vol. 13 (3), pp. 360-5. - Publication Year :
- 1992
-
Abstract
- Complex stenosis morphology is frequently seen in patients with unstable angina. However, its relation to transient myocardial ischaemia and clinical outcome has not been adequately elucidated. We studied 86 patients admitted to the Coronary Care Unit for unstable angina; all patients underwent ECG Holter monitoring during the first 2-4 days, while receiving intensive triple drug treatment. Coronary angiography and subsequent analysis of the ischaemia-related artery were performed within 12 days of admission. Patients were grouped according to their angiographic features: 45 showed complex coronary morphology (CM: 29 eccentric stenosis with irregular borders or overhanging edges; 16 intracoronary thrombus), 11 had documented coronary spasm as well as moderate atherosclerosis (CS), seven had left main coronary artery disease, and the remaining 23 patients showed regular and smooth morphology of coronary stenosis (RM). At admission, transient myocardial ischaemia (TMI) was greater in patients with CM (85 +/- 60 min .24 h-1) than in those with RM or CS (33 +/- 26 min .24 h-1; P less than 0.005). After 3 days of full medical treatment TMI decreased in all groups, but 34/45 patients with CM and 9/34 with RM or CS still showed residual ischaemia (greater than 0 min .24 h-1): 76% vs 26%, P less than 0.02. Follow-up was obtained at hospital discharge and after 1 year in all patients.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Aged
Angina, Unstable complications
Angina, Unstable mortality
Coronary Angiography
Coronary Disease diagnostic imaging
Coronary Disease epidemiology
Electrocardiography, Ambulatory
Female
Hospital Mortality
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Risk Factors
Survival Rate
Angina, Unstable drug therapy
Coronary Disease etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0195-668X
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 1597223
- Full Text :
- https://doi.org/10.1093/oxfordjournals.eurheartj.a060175