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Worms can worsen malaria: towards a new means to roll back malaria?
- Source :
-
Trends in parasitology [Trends Parasitol] 2005 Aug; Vol. 21 (8), pp. 359-62. - Publication Year :
- 2005
-
Abstract
- Recent studies in Africa and Asia indicate that different helminthic infections adversely affect the clinical outcome of malaria infections. This suggests that helminths can influence the acquisition of immunity against Plasmodium. Worms could constitute a confounding factor in the assessment of efficacy of malaria-control intervention, including vaccine prototypes in clinical trials. These observations have fundamental and practical consequences; if the deleterious effect of worms on malaria is confirmed, treatment of helminths would offer an affordable, strongly effective and novel means to roll back malaria. With this article, we hope to induce others to conduct similar studies in different regions.
- Subjects :
- Animals
Anthelmintics therapeutic use
Helminthiasis drug therapy
Helminthiasis immunology
Humans
Immunoglobulin Isotypes immunology
Malaria complications
Malaria immunology
Malaria prevention & control
Helminthiasis complications
Helminths immunology
Malaria parasitology
Plasmodium immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4922
- Volume :
- 21
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Trends in parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 15967721
- Full Text :
- https://doi.org/10.1016/j.pt.2005.06.011