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Identification and expansion of pancreatic stem/progenitor cells.
- Source :
-
Journal of cellular and molecular medicine [J Cell Mol Med] 2005 Apr-Jun; Vol. 9 (2), pp. 331-44. - Publication Year :
- 2005
-
Abstract
- Pancreatic islet transplantation represents an attractive approach for the treatment of diabetes. However, the limited availability of donor islets has largely hampered this approach. In this respect, the use of alternative sources of islets such as the ex vivo expansion and differentiation of functional endocrine cells for treating diabetes has become the major focus of diabetes research. Adult pancreatic stem cells /progenitor cells have yet to be recognized because limited markers exist for their identification. While the pancreas has the capacity to regenerate under certain circumstances, questions where adult pancreatic stem/progenitor cells are localized, how they are regulated, and even if the pancreas harbors a stem cell population need to be resolved. In this article, we review the recent achievements both in the identification as well as in the expansion of pancreatic stem/progenitor cells.
- Subjects :
- Animals
Cell Differentiation physiology
Embryo, Mammalian cytology
Humans
Insulin metabolism
Islets of Langerhans cytology
Islets of Langerhans metabolism
Models, Biological
Pancreas physiology
Pancreatic Ducts cytology
Pancreatic Ducts metabolism
Regeneration physiology
Stem Cells physiology
Cell Proliferation
Pancreas cytology
Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1582-1838
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of cellular and molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 15963253
- Full Text :
- https://doi.org/10.1111/j.1582-4934.2005.tb00359.x