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Biosynthetic origins of C-P bond containing tripeptide K-26.
- Source :
-
Organic letters [Org Lett] 2005 Jun 23; Vol. 7 (13), pp. 2763-5. - Publication Year :
- 2005
-
Abstract
- [reaction: see text] Primary metabolic precursors for K-26, a naturally occurring tripeptide phosphonic acid from Actinomyces sp. K-26, are investigated by heavy-atom isotope labeled substrate incorporation experiments. A highly sensitive selected reaction monitoring (SRM)-based method for isotopic incorporation estimation in natural products is reported. The incorporation of heavy-atom isotope labeled tyrosine compounds into the (R)-1-amino-2-(4-hydroxyphenyl)-ethylphosphonic acid moiety of compound K-26 suggests a new mechanism of biosynthesis of phosphonate functionality in natural products.
Details
- Language :
- English
- ISSN :
- 1523-7060
- Volume :
- 7
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 15957941
- Full Text :
- https://doi.org/10.1021/ol051091d